Drug Bioavailability Enhancement

Effective drug development depends on drug bioavailability - the proportion of an administered dose that reaches systemic circulation in an active form. For oral drugs, bioavailability is a major challenge, as poor solubility and permeability often limit absorption.

We specialize in enhancing the bioavailability of oral drugs using cutting-edge formulation techniques to improve solubility and dissolution rates. Our expertise in lipid-based systems and amorphous solid dispersion (ASD) ensures that your drug candidates achieve optimal absorption and therapeutic efficacy.

Our services include comprehensive bioavailability enhancement solutions, from formulation development, through to regulatory-compliant manufacturing, to help pharmaceutical companies bring more effective oral drugs to market.

Our Bioavailability Capabilities

Next to lipid-based systems, our expertise specializes in amorphous solid dispersion (ASD) - a proven approach for overcoming poor drug solubility and maximizing therapeutic performance. Our technologies and expertise focus on improving solubility and absorption to enhance drug bioavailability.

Spray Drying

Spray Drying is one of Aenova’s highly effective technology solutions for oral bioavailability enhancement, of which we offer state-of-the-art spray drying setup with laboratory to GMP production equipment by renowned manufacturers.

Technology & Equipment

• Laboratory scale for development
• GMP equipment (GEA), APIs up to OEB 4 (>1 µg/m³)
• Organic solvents handling
• University collaborations for access to the latest developments and research specialists, enabling us to find innovative solutions for complex processes and formulations
• Full set of analytical methods in-house

Hot Melt Extrusion

Our hot melt extrusion technology is an effective solution for improving the solubility and bioavailability of API’s and poorly water-soluble drugs to make them more therapeutically effective. Our approach ensures seamless scalability from early formulation screening to GMP production, enabling efficient bioavailability optimization across all clinical phases.

Technology & Equipment

• Simulation with minimal API consumption
• Laboratory scale for development
• GMP equipment (Leistritz), APIs up to OEB 5 (<1 µg/m³)
• Collaboration with equipment specialist Leistritz
• Full set of analytical methods in-house

Analytical Services for Optimizing Drug Bioavailability

To support bioavailability development, we utilize analytical evaluation via our in-house analytical capabilities to enhance drug solubility and absorption. Our specialized analytical team ensure that each formulation is optimized for maximum therapeutic efficacy to support the successful development of your pharmaceutical products - from initial trials to process validation - in full compliance with cGMP requirements.

Customized End-to-End Development Services

Aenova offers high-quality, end-to-end contract development services, with a focus on spray drying and hot melt extrusion capabilities for bioavailability. From early-phase development to pilot scale, we help reduce your time to clinic and avoid transfer risks. Our seamless integration of formulation development, analytical testing, and scalable manufacturing ensures efficient process optimization and regulatory support.

Why Choose Aenova for Bioavailability?

Our advanced formulation technologies, combined with state-of-the-art analytical services, ensure optimized drug absorption and stability.

With decades of experience, dedicated Centers of Excellence, and a lot of passion, we help pharmaceutical pioneers accelerate drug development and enhance therapeutic performance for patients. Our scientific expertise, advanced technologies, and analytical excellence make us the ideal partner for bioavailability solutions and drug formulation optimization.

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Ready to partner with us for industry-leading bioavailability solutions?
Contact us today to speak to our team of experts for support and consultation.

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